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Vitamin D
 
cofactor
Summary

Vitamin D is a group of fat-soluble prohormones, the two major forms of which are vitamin D2 (or ergocalciferol) and vitamin D3 (or cholecalciferol). The term vitamin D also refers to metabolites and other analogues of these substances. Vitamin D3 is produced in skin exposed to sunlight, specifically ultraviolet B radiation.

“Vitamin D - Wikidoc.” Wikidoc.org, 2013, www.wikidoc.org/index.php/Vitamin_D

Benefits
1.
promotes the activation of tyrosine hydroxylase, an essential enzyme in the synthesis of dopamine and noradrenaline [1][3]
2.
activates serotonin production [2]
Deficiency Factors
vegan diet, lack of sun exposure

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Applications & Precautions
Applications
Insomnia
Precautions
Excessive vitamin D supplementation without adequate vitamin K (from diet or supplementation) may contribute to atherosclerosis (hardening of the arteries) [3]. The most common sign of 'vitamin D overload' is oily hair or skin.
Important Notes
Being that vitamin D is a fat-soluble vitamin (and can be stored), a single daily dose can be administered rather than multiple {smaller) doses.
Dosage Guidelines
Dosing Range
2000
-
6000
IU
Dose Increment
2000
IU
Maximum Daily
10000
IU
Best absorbed
with food
Recommended Products
Vitamin D-3 2,000 IU - NOW Order from Amazon 
Vitamin D3 5000 IU Softgels - Blue Bonnet Order from Amazon 

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References
1. 
Trinko, Joseph R., et al. “Vitamin D3: A Role in Dopamine Circuit Regulation, Diet-Induced Obesity, and Drug Consumption.” Eneuro, vol. 3, no. 3, May 2016, pp. ENEURO.0122-15.2016, www.ncbi.nlm.nih.gov/pmc/articles/PMC4875352/, 10.1523/eneuro.0122-15.2016.
2. 
Patrick, Rhonda P., and Bruce N. Ames. “Vitamin D and the Omega‐3 Fatty Acids Control Serotonin Synthesis and Action, Part 2: Relevance for ADHD, Bipolar Disorder, Schizophrenia, and Impulsive Behavior.” The FASEB Journal, vol. 29, no. 6, 24 Feb. 2015, pp. 2207–2222, pubmed.ncbi.nlm.nih.gov/25713056/, 10.1096/fj.14-268342.
3. 
Kim, Sang-Hyun, et al. “Relationship between Serum Vitamin D Levels and Symptoms of Depression in Stroke Patients.” Annals of Rehabilitation Medicine, vol. 40, no. 1, 2016, p. 120, www.ncbi.nlm.nih.gov/pmc/articles/PMC4775744/, 10.5535/arm.2016.40.1.120.
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These icons appear on items to indicate the affected neurotransmitter(s).
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Dopaminergic. promotes the synthesis or activity of dopamine.

Endorphinergic. promotes the synthesis or activity of endorphins.

noradrenergic

Noradrenergic. promotes the synthesis or activity of noradrenaline.

Cholinergic. promotes the synthesis or activity of acetylcholine.

gabanergic

GABAnergic. promotes the synthesis or activity of GABA.

Serotonergic. promotes the synthesis or activity of serotonin.

These icons appear on items to indicate the optimal time-of-day.
rising

Rising. sunrise to mid-morning.

2-midmorning

Morning. mid-morning to noon.

3-noon

Noon. noon to mid-afternoon.

5-sunset

Afternoon. mid-afternoon to sunset.

evening

Evening. sunset to bedtime.

These icons appear on items to indicate additional benefits & important alerts.

Synergistic. combining with another supplement may increase potency.

Methylation agent. increases or decreases methylation of neurotransmitters.

Cortisol modulator. affects the synthesis or activity of the stress hormone cortisol.

Glucose regulator. attenuates changes in blood sugar levels.

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Neurotransmitter Scores

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Achievements

Neurotransmitter Scores

Dopamine

 

??

Endorphin

 

??

Noradrenaline

 

??

Acetylcholine

 

??

GABA

 

??

Serotonin

 

??

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