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Vitamin C
 
cofactor
Summary

Vitamin C or L-ascorbate is an essential nutrient for higher primates, and a small number of other species. The presence of ascorbate is required for a range of essential metabolic reactions in all animals and plants. It is made internally by almost all organisms, humans being one notable exception...In humans, vitamin C is a highly effective antioxidant, acting to lessen oxidative stress, a substrate for ascorbate peroxidase, as well as an enzyme cofactor for the biosynthesis of many important biochemicals.

“Vitamin c - Wikidoc.” Wikidoc.org, 2012, www.wikidoc.org/index.php/Vitamin_C

Benefits
1.
may lower stress hormone by attenuating the release of cortisol [1]
2.
upregulates the synthesis of beta-endorphin [2]
3.
promotes the synthesis of noradrenaline from dopamine by serving as an essential cofactor [3]
Deficiency Factors
alcohol consumption, dietary insufficiency

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Applications & Precautions
Applications
Alcohol Detox, Burnout, Caffeine Detox, Sugar Detox
Important Notes
Ascorbyl Palmitate is a specific form of vitamin c that is both water and lipid soluble. Research has shown that this form is more bioavailable to brain tissue (compared to typical ascorbate) and therefore may be better suited for affecting neurotransmitters. [4]
Dosage Guidelines
Dosing Range
200
-
400
mg
Dose Increment
200
mg
Maximum Daily
800
mg
Best absorbed
with food
Recommended Products
Ascorbyl Palmitate 500 mg - NOW Order from %seller% 
Ascorbyl Palmitate 500mg - Life Extension Order from %seller% 

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References
1. 
Peters, E. M., et al. “Vitamin c Supplementation Attenuates the Increases in Circulating Cortisol, Adrenaline and Anti-Inflammatory Polypeptides Following Ultramarathon Running.” International Journal of Sports Medicine, vol. 22, no. 7, Oct. 2001, pp. 537–543, pubmed.ncbi.nlm.nih.gov/11590482/, 10.1055/s-2001-17610. ‌
2. 
Carr, Anitra C., and Cate McCall. “The Role of Vitamin c in the Treatment of Pain: New Insights.” Journal of Translational Medicine, vol. 15, no. 1, 14 Apr. 2017, 10.1186/s12967-017-1179-7.
3. 
Plevin, David, and Cherrie Galletly. “The Neuropsychiatric Effects of Vitamin c Deficiency: A Systematic Review.” BMC Psychiatry, vol. 20, no. 1, 18 June 2020, bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-020-02730-w, 10.1186/s12888-020-02730-w. ‌
4. 
Pokorski, Mieczysław, et al. “Ascorbyl Palmitate as a Carrier of Ascorbate into Neural Tissues.” Journal of Biomedical Science, vol. 10, no. 2, Mar. 2003, pp. 193–198, link.springer.com/article/10.1007/BF02256054, 10.1007/bf02256054
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These icons appear on items to indicate the affected neurotransmitter(s).
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Dopaminergic. promotes the synthesis or activity of dopamine.

Endorphinergic. promotes the synthesis or activity of endorphins.

noradrenergic

Noradrenergic. promotes the synthesis or activity of noradrenaline.

Cholinergic. promotes the synthesis or activity of acetylcholine.

gabanergic

GABAnergic. promotes the synthesis or activity of GABA.

Serotonergic. promotes the synthesis or activity of serotonin.

These icons appear on items to indicate the optimal time-of-day.
rising

Rising. sunrise to mid-morning.

2-midmorning

Morning. mid-morning to noon.

3-noon

Noon. noon to mid-afternoon.

5-sunset

Afternoon. mid-afternoon to sunset.

evening

Evening. sunset to bedtime.

These icons appear on items to indicate additional benefits & important alerts.

Synergistic. combining with another supplement may increase potency.

Methylation agent. increases or decreases methylation of neurotransmitters.

Cortisol modulator. affects the synthesis or activity of the stress hormone cortisol.

Glucose regulator. attenuates changes in blood sugar levels.

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