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Vitamin B6
 
cofactor
Summary

Vitamin B6 is a water-soluble vitamin. Pyridoxal phosphate (PLP) is the active form and is a cofactor in many reactions of amino acid metabolism, including transamination, deamination, and decarboxylation. PLP also is necessary for the enzymatic reaction governing the release of glucose from glycogen.

“Vitamin B6 - Wikidoc.” Wikidoc.org, 2022, www.wikidoc.org/index.php/Vitamin_B6

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Benefits
1.
supports optimal levels of dopamine, GABA, and serotonin as a synthesis cofactor. [1]
Deficiency Factors
alcohol consumption

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Applications & Precautions
Important Notes
Vitamin B6 intake has a biphasic effect, whereby both deficient and excessive amounts deplete several neurotransmitters. The effective dose range seems to be between 1x and 100x the RDI. [2]
Dosage Guidelines
Dosing Range
50
-
100
mg
Dose Increment
50
mg
Maximum Daily
100
mg
Best absorbed
with food
Recommended Products
Kal 50 Mg B-6 Pyridoxal-5-phosphate Tablets - KAL Order from Amazon 
Pyridoxal 5-Phosphate 100 mg - Monoherb Order from Amazon 

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References
1. 
Kennedy, David. “B Vitamins and the Brain: Mechanisms, Dose and Efficacy—a Review.” Nutrients, vol. 8, no. 2, 27 Jan. 2016, p. 68, www.ncbi.nlm.nih.gov/pmc/articles/PMC4772032/, 10.3390/nu8020068.
2. 
Schaeffer, Monica C., et al. “Dietary Excess of Vitamin B-6 Affects the Concentrations of Amino Acids in the Caudate Nucleus and Serum and the Binding Properties of Serotonin Receptors in the Brain Cortex of Rats.” The Journal of Nutrition, vol. 128, no. 10, 1 Oct. 1998, pp. 1829–1835, academic.oup.com/jn/article/128/10/1829/4723060?login=false, 10.1093/jn/128.10.1829.
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These icons appear on items to indicate the affected neurotransmitter(s).
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Dopaminergic. promotes the synthesis or activity of dopamine.

Endorphinergic. promotes the synthesis or activity of endorphins.

noradrenergic

Noradrenergic. promotes the synthesis or activity of noradrenaline.

Cholinergic. promotes the synthesis or activity of acetylcholine.

gabanergic

GABAnergic. promotes the synthesis or activity of GABA.

Serotonergic. promotes the synthesis or activity of serotonin.

These icons appear on items to indicate the optimal time-of-day.
rising

Rising. sunrise to mid-morning.

2-midmorning

Morning. mid-morning to noon.

3-noon

Noon. noon to mid-afternoon.

5-sunset

Afternoon. mid-afternoon to sunset.

evening

Evening. sunset to bedtime.

These icons appear on items to indicate additional benefits & important alerts.

Synergistic. combining with another supplement may increase potency.

Methylation agent. increases or decreases methylation of neurotransmitters.

Cortisol modulator. affects the synthesis or activity of the stress hormone cortisol.

Glucose regulator. attenuates changes in blood sugar levels.

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