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Benfotiamine B1
 
cofactor
Summary

"Benfotiamine, also known as S-benzoylthiamine-O-monophosphate, is a lipid-soluble derivative of vitamin B1 (thiamine) and is absorbed up to 3.6 times more than water-soluble forms. Vitamin B1 is associated with a 120-fold greater increase in the levels of metabolically active thiamine diphosphate. Its lipid solubility allows it to penetrate the nerves more readily. It has been found to provide a higher bioavailability of thiamine than its water-soluble counterparts."

- David Rakel, Integrative Medicine (Fourth Edition), Elsevier 2018, ISBN 9780323358682,
https://doi.org/10.1016/B978-0-323-35868-2.12001-8

Benefits
1.
May reduce symptoms of depression caused by vitamin B1 deficiency [1]
2.
Supports acetylcholine production as an essential cofactor for the precursor pyruvate [2][3]
Deficiency Factors
alcohol consumption, caffeine consumption, sugar consumption

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Applications & Precautions
Important Notes
Benfotiamine produces the best results when taken in 2 doses spread throughout the day.
Dosage Guidelines
Dosing Range
150
-
300
mg
Dose Increment
150
mg
Maximum Daily
600
mg
Best absorbed
with food
Recommended Products
Benfotiamine 150mg - Source Naturals Order from %seller% 
Benfotiamine 300mg - Nutricost Order from %seller% 

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References
1. 
Manzardo, Ann M., et al. “Change in Psychiatric Symptomatology after Benfotiamine Treatment in Males Is Related to Lifetime Alcoholism Severity.” Drug and Alcohol Dependence, vol. 152, July 2015, pp. 257–263, www.ncbi.nlm.nih.gov/pmc/articles/PMC4550087/, 10.1016/j.drugalcdep.2015.03.032.
2. 
Gibson, Gary E., et al. “Correlation of Enzymatic, Metabolic, and Behavioral Deficits in Thiamin Deficiency and Its Reversal.” Neurochemical Research, vol. 9, no. 6, June 1984, pp. 803–814, link.springer.com/article/10.1007/BF00965667, 10.1007/bf00965667.
3. 
Jope, Richard S., and Donald J. Jenden. “The Utilization of Choline and Acetyl Coenzyme a for the Synthesis of Acetylcholine.” Journal of Neurochemistry, vol. 35, no. 2, Aug. 1980, pp. 318–325, pubmed.ncbi.nlm.nih.gov/7452263/, 10.1111/j.1471-4159.1980.tb06267.x.
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These icons appear on items to indicate the affected neurotransmitter(s).
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Dopaminergic. promotes the synthesis or activity of dopamine.

Endorphinergic. promotes the synthesis or activity of endorphins.

noradrenergic

Noradrenergic. promotes the synthesis or activity of noradrenaline.

Cholinergic. promotes the synthesis or activity of acetylcholine.

gabanergic

GABAnergic. promotes the synthesis or activity of GABA.

Serotonergic. promotes the synthesis or activity of serotonin.

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Noon. noon to mid-afternoon.

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Afternoon. mid-afternoon to sunset.

evening

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These icons appear on items to indicate additional benefits & important alerts.

Synergistic. combining with another supplement may increase potency.

Methylation agent. increases or decreases methylation of neurotransmitters.

Cortisol modulator. affects the synthesis or activity of the stress hormone cortisol.

Glucose regulator. attenuates changes in blood sugar levels.

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