Benfotiamine B1
cofactor
Summary
"Benfotiamine, also known as S-benzoylthiamine-O-monophosphate, is a lipid-soluble derivative of vitamin B1 (thiamine) and is absorbed up to 3.6 times more than water-soluble forms. Vitamin B1 is associated with a 120-fold greater increase in the levels of metabolically active thiamine diphosphate. Its lipid solubility allows it to penetrate the nerves more readily. It has been found to provide a higher bioavailability of thiamine than its water-soluble counterparts."
- David Rakel, Integrative Medicine (Fourth Edition), Elsevier 2018, ISBN 9780323358682,
https://doi.org/10.1016/B978-0-323-35868-2.12001-8
Benefits
1.
May reduce symptoms of depression caused by vitamin B1 deficiency [1]
2.
Supports acetylcholine production as an essential cofactor for the precursor pyruvate [2][3]
Deficiency Factors
alcohol consumption, caffeine consumption, sugar consumption
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Applications & Precautions
Important Notes
Benfotiamine produces the best results when taken in 2 doses spread throughout the day.
Dosage Guidelines
150
300
mg
150
mg
600
mg
with food
Recommended Products
Benfotiamine 150mg - Source Naturals
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Benfotiamine 300mg - Nutricost
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References
1.
Manzardo, Ann M., et al. “Change in Psychiatric Symptomatology after Benfotiamine Treatment in Males Is Related to Lifetime Alcoholism Severity.” Drug and Alcohol Dependence, vol. 152, July 2015, pp. 257–263, www.ncbi.nlm.nih.gov/pmc/articles/PMC4550087/, 10.1016/j.drugalcdep.2015.03.032.
2.
Gibson, Gary E., et al. “Correlation of Enzymatic, Metabolic, and Behavioral Deficits in Thiamin Deficiency and Its Reversal.” Neurochemical Research, vol. 9, no. 6, June 1984, pp. 803–814, link.springer.com/article/10.1007/BF00965667, 10.1007/bf00965667.
3.
Jope, Richard S., and Donald J. Jenden. “The Utilization of Choline and Acetyl Coenzyme a for the Synthesis of Acetylcholine.” Journal of Neurochemistry, vol. 35, no. 2, Aug. 1980, pp. 318–325, pubmed.ncbi.nlm.nih.gov/7452263/, 10.1111/j.1471-4159.1980.tb06267.x.
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