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Methylfolate
 
cofactor
Summary

"Levomefolic acid (INN, also known as L-5-MTHF, L-methylfolate and L-5-methyltetrahydrofolate and (6S)-5-methyltetrahydrofolate, and (6S)-5-MTHF) is the primary biologically active form of folate used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine...The un-methylated form, folic acid (vitamin B9), is a synthetic form of folate, and must undergo enzymatic reduction by dihydrofolate reductase (DHFR) to become biologically active."

“Levomefolic Acid.” Wikipedia, Wikimedia Foundation, 28 Feb. 2022, en.wikipedia.org/wiki/Levomefolic_acid.

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Benefits
1.
may reduce symptoms of anxiety caused by overmethylation [1]
2.
supports cardiovascular health by reducing homocysteine levels [2]
Deficiency Factors

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Applications & Precautions
Precautions
Taking methylfolate can lead to vitamin B12 deficiency. Consider 'preloading' B12 before taking any folate supplement regularly. [1]

5-MTHF is contraindicated for individuals with symptoms of undermethylation.

Increasing dose amount incrementally is generally recommended to avoid side effects.
Dosage Guidelines
Dosing Range
1000
-
3000
mcg
Dose Increment
1000
mcg
Maximum Daily
7000
mcg
Best absorbed
with food
Recommended Products
Methyl Folate 1000 mcg - Blue Bonnet Order from Amazon 
Optimized L-Methylfolate 1700 mcg - Life Extension Order from Amazon 

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References
1. 
SCOTT, J. “THE METHYL FOLATE TRAP a Physiological Response in Man to Prevent Methyl Group Deficiency in Kwashiorkor (Methionine Deficiency) and an Explanation for Folic-Acid-Induced Exacerbation of Subacute Combined Degeneration in Pernicious Anaemia.” The Lancet, vol. 318, no. 8242, Aug. 1981, pp. 337–340, pubmed.ncbi.nlm.nih.gov/6115113/, 10.1016/s0140-6736(81)90650-4.
2. 
“Homocysteine Lowering with Folic Acid and B Vitamins in Vascular Disease.” New England Journal of Medicine, vol. 354, no. 15, 13 Apr. 2006, pp. 1567–1577, www.nejm.org/doi/full/10.1056/nejmoa060900, 10.1056/nejmoa060900. Accessed 24 Aug. 2021.
3. 
“L-Methylfolate Dosage.” Drugs.com, Drugs.com, 2021, www.drugs.com/dosage/l-methylfolate.html. Accessed 24 Aug. 2021.
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These icons appear on items to indicate the affected neurotransmitter(s).
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Dopaminergic. promotes the synthesis or activity of dopamine.

Endorphinergic. promotes the synthesis or activity of endorphins.

noradrenergic

Noradrenergic. promotes the synthesis or activity of noradrenaline.

Cholinergic. promotes the synthesis or activity of acetylcholine.

gabanergic

GABAnergic. promotes the synthesis or activity of GABA.

Serotonergic. promotes the synthesis or activity of serotonin.

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evening

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These icons appear on items to indicate additional benefits & important alerts.

Synergistic. combining with another supplement may increase potency.

Methylation agent. increases or decreases methylation of neurotransmitters.

Cortisol modulator. affects the synthesis or activity of the stress hormone cortisol.

Glucose regulator. attenuates changes in blood sugar levels.

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