Methylfolate
cofactor
Summary
"Levomefolic acid (INN, also known as L-5-MTHF, L-methylfolate and L-5-methyltetrahydrofolate and (6S)-5-methyltetrahydrofolate, and (6S)-5-MTHF) is the primary biologically active form of folate used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine...The un-methylated form, folic acid (vitamin B9), is a synthetic form of folate, and must undergo enzymatic reduction by dihydrofolate reductase (DHFR) to become biologically active."
“Levomefolic Acid.” Wikipedia, Wikimedia Foundation, 28 Feb. 2022, en.wikipedia.org/wiki/Levomefolic_acid.
Benefits
1.
may reduce symptoms of anxiety caused by overmethylation [1]
2.
supports cardiovascular health by reducing homocysteine levels [2]
Deficiency Factors
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Applications & Precautions
Precautions
Taking methylfolate can lead to vitamin B12 deficiency. Consider 'preloading' B12 before taking any folate supplement regularly. [1]
5-MTHF is contraindicated for individuals with symptoms of undermethylation.
Increasing dose amount incrementally is generally recommended to avoid side effects.
Dosage Guidelines
1000
3000
mcg
1000
mcg
7000
mcg
with food
Recommended Products
Methyl Folate 1000 mcg - Blue Bonnet
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Optimized L-Methylfolate 1700 mcg - Life Extension
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References
1.
SCOTT, J. “THE METHYL FOLATE TRAP a Physiological Response in Man to Prevent Methyl Group Deficiency in Kwashiorkor (Methionine Deficiency) and an Explanation for Folic-Acid-Induced Exacerbation of Subacute Combined Degeneration in Pernicious Anaemia.” The Lancet, vol. 318, no. 8242, Aug. 1981, pp. 337–340, pubmed.ncbi.nlm.nih.gov/6115113/, 10.1016/s0140-6736(81)90650-4.
2.
“Homocysteine Lowering with Folic Acid and B Vitamins in Vascular Disease.” New England Journal of Medicine, vol. 354, no. 15, 13 Apr. 2006, pp. 1567–1577, www.nejm.org/doi/full/10.1056/nejmoa060900, 10.1056/nejmoa060900. Accessed 24 Aug. 2021.
3.
“L-Methylfolate Dosage.” Drugs.com, Drugs.com, 2021, www.drugs.com/dosage/l-methylfolate.html. Accessed 24 Aug. 2021.
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