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Magnesium
 
cofactor
Summary
Benefits
1.
potentiates the response of GABA receptors in the brain [1] [3]
2.
promotes neuronal regeneration by increasing BDNF [2]
3.
Supports synthesis of multiple neurotransmitters by serving as a cofactor in related enzymatic processes [4]
4.
Promotes serotonergic transmission by potentiating serotonin receptors [4]
Deficiency Factors
alcohol consumption, caffeine consumption, sugar consumption

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Dosage Guidelines
Dosing Range
-
mg
Dose Increment
mg
Maximum Daily
mg
Best absorbed
without food
Recommended Products

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References
1. 
Möykkynen, Tommi, et al. “Magnesium Potentiation of the Function of Native and Recombinant GABAA Receptors.” Neuroreport, vol. 12, no. 10, July 2001, pp. 2175–2179, pubmed.ncbi.nlm.nih.gov/11447329/, 10.1097/00001756-200107200-00026.
2. 
Slutsky, Inna, et al. “Enhancement of Learning and Memory by Elevating Brain Magnesium.” Neuron, vol. 65, no. 2, Jan. 2010, pp. 165–177, www.sciencedirect.com/science/article/pii/S0896627309010447, 10.1016/j.neuron.2009.12.026.
3. 
Poleszak E. “Benzodiazepine/GABA(A) Receptors Are Involved in Magnesium-Induced Anxiolytic-like Behavior in Mice.” Pharmacological Reports : PR, vol. 60, no. 4, 2018, pubmed.ncbi.nlm.nih.gov/18799816/.
4. 
Cuciureanu, Magdalena D, and Robert Vink. “Magnesium and Stress.” Nih.gov, University of Adelaide Press, 2020, www.ncbi.nlm.nih.gov/books/NBK507250/.
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These icons appear on items to indicate the affected neurotransmitter(s).
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Dopaminergic. promotes the synthesis or activity of dopamine.

Endorphinergic. promotes the synthesis or activity of endorphins.

noradrenergic

Noradrenergic. promotes the synthesis or activity of noradrenaline.

Cholinergic. promotes the synthesis or activity of acetylcholine.

gabanergic

GABAnergic. promotes the synthesis or activity of GABA.

Serotonergic. promotes the synthesis or activity of serotonin.

These icons appear on items to indicate the optimal time-of-day.
rising

Rising. sunrise to mid-morning.

2-midmorning

Morning. mid-morning to noon.

3-noon

Noon. noon to mid-afternoon.

5-sunset

Afternoon. mid-afternoon to sunset.

evening

Evening. sunset to bedtime.

These icons appear on items to indicate additional benefits & important alerts.

Synergistic. combining with another supplement may increase potency.

Methylation agent. increases or decreases methylation of neurotransmitters.

Cortisol modulator. affects the synthesis or activity of the stress hormone cortisol.

Glucose regulator. attenuates changes in blood sugar levels.

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Neurotransmitter Scores

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GABA

 

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Achievements

Neurotransmitter Scores

Dopamine

 

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Endorphin

 

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Acetylcholine

 

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GABA

 

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Serotonin

 

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