supplements
Magnesium
GABAnergic. involved in the production or activation of GABA.
Serotonergic. involved in the production or activation of serotonin.
cofactor
Summary
Benefits
1.
potentiates the response of GABA receptors in the brain [1] [3]
2.
promotes neuronal regeneration by increasing BDNF [2]
3.
Supports synthesis of multiple neurotransmitters by serving as a cofactor in related enzymatic processes [4]
4.
Promotes serotonergic transmission by potentiating serotonin receptors [4]
Deficiency Factors
alcohol consumption, caffeine consumption, sugar consumption
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Dosage Guidelines
Dosing Range
-
mg
Dose Increment
mg
Maximum Daily
mg
Best absorbed
without food
Recommended Products
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References
1.
Möykkynen, Tommi, et al. “Magnesium Potentiation of the Function of Native and Recombinant GABAA Receptors.” Neuroreport, vol. 12, no. 10, July 2001, pp. 2175–2179, pubmed.ncbi.nlm.nih.gov/11447329/, 10.1097/00001756-200107200-00026.
2.
Slutsky, Inna, et al. “Enhancement of Learning and Memory by Elevating Brain Magnesium.” Neuron, vol. 65, no. 2, Jan. 2010, pp. 165–177, www.sciencedirect.com/science/article/pii/S0896627309010447, 10.1016/j.neuron.2009.12.026.
3.
Poleszak E. “Benzodiazepine/GABA(A) Receptors Are Involved in Magnesium-Induced Anxiolytic-like Behavior in Mice.” Pharmacological Reports : PR, vol. 60, no. 4, 2018, pubmed.ncbi.nlm.nih.gov/18799816/.
4.
Cuciureanu, Magdalena D, and Robert Vink. “Magnesium and Stress.” Nih.gov, University of Adelaide Press, 2020, www.ncbi.nlm.nih.gov/books/NBK507250/.
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