Lithium Orotate
augmentor
Summary
"Lithium orotate (C5H3LiN2O4), is a salt of orotic acid and lithium... It is marketed as a dietary supplement, though it has been researched minimally between 1973–1986 to treat certain medical conditions, such as alcoholism[2] and Alzheimer's disease."
“Lithium Orotate.” Wikipedia, Wikimedia Foundation, 19 Feb. 2022, en.wikipedia.org/wiki/Lithium_orotate.
Benefits
1.
may reduce feelings of mania by inhibiting the release of dopamine [1]
2.
may reduce agitation associated with depression by increasing GABA activity and inhibiting glutamate transmission [1]
3.
neuroprotective and neuroproliferative for several brain regions related to depression [2]
Deficiency Factors
dietary insufficiency
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Applications & Precautions
Important Notes
While lithium toxicity is possible, the dosage required is only feasible with prescription-only forms.
Dosage Guidelines
5
10
mg
5
mg
30
mg
with food
Recommended Products
Lithium Orotate 5mg - Nutricost
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References
1.
Malhi, Gin S., et al. “Potential Mechanisms of Action of Lithium in Bipolar Disorder.” CNS Drugs, vol. 27, no. 2, Feb. 2013, pp. 135–153, link.springer.com/article/10.1007/s40263-013-0039-0, 10.1007/s40263-013-0039-0.
2.
Schloesser, Robert J, et al. “Cellular Plasticity Cascades in the Pathophysiology and Treatment of Bipolar Disorder.” Neuropsychopharmacology, vol. 33, no. 1, 3 Oct. 2007, pp. 110–133, www.nature.com/articles/1301575, 10.1038/sj.npp.1301575.
3.
Menegas, Samira, et al. “Efficacy of Folic Acid as an Adjunct to Lithium Therapy on Manic-like Behaviors, Oxidative Stress and Inflammatory Parameters in an Animal Model of Mania.” Metabolic Brain Disease, vol. 35, no. 2, 15 Dec. 2019, pp. 413–425, pubmed.ncbi.nlm.nih.gov/31840201/, 10.1007/s11011-019-00503-3.
4.
Schrauzer, Gerhard N., et al. “Lithium in Scalp Hair of Adults, Students, and Violent Criminals.” Biological Trace Element Research, vol. 34, no. 2, Aug. 1992, pp. 161–176, pubmed.ncbi.nlm.nih.gov/1381936/, 10.1007/bf02785244.
5.
Nassar, Ahmad H M, and Abed N Azab. Effects of Lithium on Inflammation. Vol. 5, no. 6, 6 May 2014, pp. 451–458, www.ncbi.nlm.nih.gov/pmc/articles/PMC4063502/, https://doi.org/10.1021/cn500038f.
6.
Pacholko, Anthony G, and Lane K Bekar. Lithium Orotate: A Superior Option for Lithium Therapy? Vol. 11, no. 8, 1 July 2021, www.ncbi.nlm.nih.gov/pmc/articles/PMC8413749/, https://doi.org/10.1002/brb3.2262.
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