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Huperzine A
 
augmentor
Summary

"Huperzine A is a naturally occurring sesquiterpene alkaloid compound found in the firmoss Huperzia serrata...Huperzine A inhibits the breakdown of the neurotransmitter acetylcholine by the enzyme acetylcholinesterase. It is commonly available over the counter as a nutrient supplement, and is marketed as a cognitive enhancer for improving memory and concentration."

“Huperzine A.” Wikipedia, Wikimedia Foundation, 1 Sept. 2021, en.wikipedia.org/wiki/Huperzine_A.

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Benefits
1.
increases levels of acetylcholine by inhibiting the enzyme acetylcholinesterase [1][3]
2.
may alleviate symptoms of some forms of depression by inhibiting NMDA receptor activity [2]
Deficiency Factors

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Applications & Precautions
Precautions
With an exceptionally long half-life, Huperzine A can easily reach toxic levels that may result in nervousness, headache, and muscle twitching. Always take Huperzine A in the morning (to avoid sleep degradation) and follow manufacturer dosing guidelines.
Dosage Guidelines
Dosing Range
100
-
200
mcg
Dose Increment
100
mcg
Maximum Daily
400
mcg
Best absorbed
without food
Recommended Products
Huperzine A Capsules - Nutricost Order from %seller% 
Huperzine A - Source Naturals Order from %seller% 

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References
1. 
LIANG, Yan-qi, and Xi-can TANG. “Comparative Studies of Huperzine A, Donepezil, and Rivastigmine on Brain Acetylcholine, Dopamine, Norepinephrine, and 5-Hydroxytryptamine Levels in Freely-Moving Rats.” Acta Pharmacologica Sinica, vol. 27, no. 9, Sept. 2006, pp. 1127–1136, pubmed.ncbi.nlm.nih.gov/16923332/, 10.1111/j.1745-7254.2006.00411.x.
2. 
Zhang, J.-M, and G.-Y Hu. “Huperzine A, a Nootropic Alkaloid, Inhibits N-Methyl-D-Aspartate-Induced Current in Rat Dissociated Hippocampal Neurons.” Neuroscience, vol. 105, no. 3, Aug. 2001, pp. 663–669, pubmed.ncbi.nlm.nih.gov/11516831/, 10.1016/s0306-4522(01)00206-8.
3. 
Wang, Rui, and Xi Can Tang. “Neuroprotective Effects of Huperzine A.” Neurosignals, vol. 14, no. 1-2, 2005, pp. 71–82, www.karger.com/Article/Abstract/85387, 10.1159/000085387.
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These icons appear on items to indicate the affected neurotransmitter(s).
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Dopaminergic. promotes the synthesis or activity of dopamine.

Endorphinergic. promotes the synthesis or activity of endorphins.

noradrenergic

Noradrenergic. promotes the synthesis or activity of noradrenaline.

Cholinergic. promotes the synthesis or activity of acetylcholine.

gabanergic

GABAnergic. promotes the synthesis or activity of GABA.

Serotonergic. promotes the synthesis or activity of serotonin.

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rising

Rising. sunrise to mid-morning.

2-midmorning

Morning. mid-morning to noon.

3-noon

Noon. noon to mid-afternoon.

5-sunset

Afternoon. mid-afternoon to sunset.

evening

Evening. sunset to bedtime.

These icons appear on items to indicate additional benefits & important alerts.

Synergistic. combining with another supplement may increase potency.

Methylation agent. increases or decreases methylation of neurotransmitters.

Cortisol modulator. affects the synthesis or activity of the stress hormone cortisol.

Glucose regulator. attenuates changes in blood sugar levels.

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