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GABA
 
precursor
Summary

"γ-Aminobutyric acid (gamma-aminobutyric acid) or GABA is the chief inhibitory neurotransmitter in the developmentally mature mammalian central nervous system. Its principal role is reducing neuronal excitability throughout the nervous system.

GABA is sold as a dietary supplement in many countries. It has been traditionally thought that exogenous GABA doesn't cross the blood-brain barrier, however data obtained from more current research describes the notion as being unclear pending further research."

“γ-Aminobutyric Acid.” Wikipedia, Wikimedia Foundation, 21 Apr. 2022, en.wikipedia.org/wiki/%CE%93-Aminobutyric_acid.

Benefits
1.
Increases systemic GABA levels, which may increase levels in the brain [3]
2.
May improve sleep continuity as well as the time it takes to fall back to sleep [2]
Deficiency Factors
caffeine consumption, dietary insufficiency

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Applications & Precautions
Important Notes
While previous research has suggested that GABA supplements do not readily cross the blood-brain-barrier, more recent research has shown that exogenous GABA may actually increase GABA in the brain. [3]
Dosage Guidelines
Dosing Range
500
-
1000
mg
Dose Increment
500
mg
Maximum Daily
mg
Best absorbed
without food
Recommended Products
Serene Science GABA - Source Naturals Order from %seller% 
GABA (Gamma-Aminobutyric Acid) + B-6 - Blue Bonnet Order from %seller% 

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References
1. 
Steenbergen, Laura, et al. “γ-Aminobutyric Acid (GABA) Administration Improves Action Selection Processes: A Randomised Controlled Trial.” Scientific Reports, vol. 5, no. 1, 31 July 2015, pubmed.ncbi.nlm.nih.gov/26227783/, 10.1038/srep12770.
2. 
Hepsomali, Piril, et al. “Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review.” Frontiers in Neuroscience, vol. 14, 17 Sept. 2020, www.frontiersin.org/articles/10.3389/fnins.2020.00923/full, 10.3389/fnins.2020.00923.
3. 
Boonstra, Evert, et al. “Neurotransmitters as Food Supplements: The Effects of GABA on Brain and Behavior.” Frontiers in Psychology, vol. 6, 6 Oct. 2015, www.ncbi.nlm.nih.gov/pmc/articles/PMC4594160/, 10.3389/fpsyg.2015.01520.
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These icons appear on items to indicate the affected neurotransmitter(s).
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Dopaminergic. promotes the synthesis or activity of dopamine.

Endorphinergic. promotes the synthesis or activity of endorphins.

noradrenergic

Noradrenergic. promotes the synthesis or activity of noradrenaline.

Cholinergic. promotes the synthesis or activity of acetylcholine.

gabanergic

GABAnergic. promotes the synthesis or activity of GABA.

Serotonergic. promotes the synthesis or activity of serotonin.

These icons appear on items to indicate the optimal time-of-day.
rising

Rising. sunrise to mid-morning.

2-midmorning

Morning. mid-morning to noon.

3-noon

Noon. noon to mid-afternoon.

5-sunset

Afternoon. mid-afternoon to sunset.

evening

Evening. sunset to bedtime.

These icons appear on items to indicate additional benefits & important alerts.

Synergistic. combining with another supplement may increase potency.

Methylation agent. increases or decreases methylation of neurotransmitters.

Cortisol modulator. affects the synthesis or activity of the stress hormone cortisol.

Glucose regulator. attenuates changes in blood sugar levels.

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