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DLPA
 
precursor
Summary

"DL-Phenylalanine is marketed as a nutritional supplement for its putative analgesic and antidepressant activities. The putative analgesic activity of DL-phenylalanine may be explained by the possible blockage by D-phenylalanine of enkephalin degradation by the enzyme carboxypeptidase A. The mechanism of DL-phenylalanine's putative antidepressant activity may be accounted for by the precursor role of L-phenylalanine in the synthesis of the neurotransmitters norepinephrine and dopamine."

“Phenylalanine - Wikidoc.” Wikidoc.org, 2022, www.wikidoc.org/index.php/Phenylalanine.

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Benefits
1.
increases beta-endorphin levels by blocking the degradation enzyme, carboxypeptidase A. [1]
2.
may increase available dopamine by providing the first-stage precursor phenylalanine. [2]
3.
may reduce withdrawal symptoms from addictive substances by inhibiting endorphin breakdown [3]
Deficiency Factors
dietary insufficiency

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Applications
Alcohol Detox, Burnout, Sugar Detox
Dosage Guidelines
Dosing Range
500
-
1500
mg
Dose Increment
500
mg
Maximum Daily
6000
mg
Best absorbed
without food
Recommended Products
DLPA DL-Phenylalanine 375 mg - Source Naturals Order from Amazon 
D L-Phenylalanine 500 mg - Life Extension Order from Amazon 

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References
1. 
Walsh. “Analgesic Effectiveness of D-Phenylalanine in Chronic Pain Patients.” Archives of Physical Medicine and Rehabilitation, vol. 67, no. 7, 2021, pubmed.ncbi.nlm.nih.gov/3524509/.
2. 
Nutrient Metabolism. Elsevier, 2003, www.sciencedirect.com/book/9780124177628/nutrient-metabolism.
3. 
Blum, Kenneth, et al. “Hypothesizing Balancing Endorphinergic and Glutaminergic Systems to Treat and Prevent Relapse to Reward Deficiency Behaviors: Coupling D-Phenylalanine and N-Acetyl-L-Cysteine (NAC) as a Novel Therapeutic Modality.” Clinical Medical Reviews and Case Reports, vol. 2, no. 12, 31 Dec. 2015, www.ncbi.nlm.nih.gov/pmc/articles/PMC4760695/, https://doi.org/10.23937/2378-3656/1410076.
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These icons appear on items to indicate the affected neurotransmitter(s).
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Dopaminergic. promotes the synthesis or activity of dopamine.

Endorphinergic. promotes the synthesis or activity of endorphins.

noradrenergic

Noradrenergic. promotes the synthesis or activity of noradrenaline.

Cholinergic. promotes the synthesis or activity of acetylcholine.

gabanergic

GABAnergic. promotes the synthesis or activity of GABA.

Serotonergic. promotes the synthesis or activity of serotonin.

These icons appear on items to indicate the optimal time-of-day.
rising

Rising. sunrise to mid-morning.

2-midmorning

Morning. mid-morning to noon.

3-noon

Noon. noon to mid-afternoon.

5-sunset

Afternoon. mid-afternoon to sunset.

evening

Evening. sunset to bedtime.

These icons appear on items to indicate additional benefits & important alerts.

Synergistic. combining with another supplement may increase potency.

Methylation agent. increases or decreases methylation of neurotransmitters.

Cortisol modulator. affects the synthesis or activity of the stress hormone cortisol.

Glucose regulator. attenuates changes in blood sugar levels.

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Acetylcholine

 

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