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Coenzyme Q10
 

Dopaminergic. involved in the synthesis or activation of dopamine.

dopaminergic
augmentor

Methylation promoter

Blood-sugar regulator.

Summary

"Coenzyme Q10 is a fat-soluble compound that is synthesized by the body and can be obtained from the diet. Coenzyme Q10 plays a central role in mitochondrial oxidative phosphorylation and the production of adenosine triphosphate (ATP). It also functions as an antioxidant in cell membranes and lipoproteins. Endogenous synthesis and dietary intake provide sufficient coenzyme Q10 to prevent deficiency in healthy people, although coenzyme Q10 concentrations in tissues decline with age."

- “Coenzyme Q10.” Linus Pauling Institute, 28 Apr. 2014, lpi.oregonstate.edu/mic/dietary-factors/coenzyme-Q10.

‌

Benefits
1.
Improves dopamine function by attenuating depletion [1]
2.
May reduce the severity of migraine headaches [2]
3.
Improves insulin resistance [3]
Deficiency Factors

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Applications & Precautions
Applications
Burnout, Sugar Detox, Undermethylation
Important Notes
CoQ10 supplementation may have no benefit to young, healthy adults. Studies have shown that persons with metabolic dysfunction (diabetes, old age) and neurodegenerative diseases are more likely to benefit from supplementation [5].
Dosage Guidelines
Dosing Range
100
-
200
mg
Dose Increment
100
mg
Maximum Daily
200
mg
Best absorbed
with food
Recommended Products

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1. 
Matthews, R. T., et al. “Coenzyme Q10 Administration Increases Brain Mitochondrial Concentrations and Exerts Neuroprotective Effects.” Proceedings of the National Academy of Sciences, vol. 95, no. 15, 21 July 1998, pp. 8892–8897, www.pnas.org/content/95/15/8892, 10.1073/pnas.95.15.8892. Accessed 16 June 2021.
2. 
Sandor, P. S., et al. “Efficacy of Coenzyme Q10 in Migraine Prophylaxis: A Randomized Controlled Trial.” Neurology, vol. 64, no. 4, 22 Feb. 2005, pp. 713–715, n.neurology.org/content/64/4/713, 10.1212/01.wnl.0000151975.03598.ed. Accessed 2 July 2021.
3. 
Zhang, Peiwen, et al. “Treatment of Coenzyme Q10 for 24 Weeks Improves Lipid and Glycemic Profile in Dyslipidemic Individuals.” Journal of Clinical Lipidology, vol. 12, no. 2, Mar. 2018, pp. 417-427.e5, pubmed.ncbi.nlm.nih.gov/29454678/, 10.1016/j.jacl.2017.12.006. Accessed 2 July 2021.
4. 
Miyamae, Takako, et al. “Increased Oxidative Stress and Coenzyme Q10 Deficiency in Juvenile Fibromyalgia: Amelioration of Hypercholesterolemia and Fatigue by Ubiquinol-10 Supplementation.” Redox Report, vol. 18, no. 1, Jan. 2013, pp. 12–19, pubmed.ncbi.nlm.nih.gov/23394493/, 10.1179/1351000212y.0000000036. Accessed 2 July 2021.
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GABA

 

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Dopaminergic. promotes the synthesis or activity of dopamine.

Endorphinergic. promotes the synthesis or activity of endorphins.

noradrenergic

Noradrenergic. promotes the synthesis or activity of noradrenaline.

Cholinergic. promotes the synthesis or activity of acetylcholine.

gabanergic

GABAnergic. promotes the synthesis or activity of GABA.

Serotonergic. promotes the synthesis or activity of serotonin.

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rising

Rising. sunrise to mid-morning.

2-midmorning

Morning. mid-morning to noon.

3-noon

Noon. noon to mid-afternoon.

5-sunset

Afternoon. mid-afternoon to sunset.

evening

Evening. sunset to bedtime.

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Synergistic. combining with another supplement may increase potency.

Methylation agent. increases or decreases methylation of neurotransmitters.

Cortisol modulator. affects the synthesis or activity of the stress hormone cortisol.

Glucose regulator. attenuates changes in blood sugar levels.