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Cannabidiol
 
augmentor
Summary

"Cannabidiol, also known as CBD, is an antipsychotic cannabinoid found in the hemp plant Cannabis sativa...CBD alone is not intoxicating, but it appears to affect the euphoric effect of THC (which is an isomer of cannabidiol) and add a sedative quality...Medically, it appears to relieve convulsion, inflammation, anxiety, and nausea, as well as inhibit cancer cell growth."

“Cannabidiol - Wikidoc.” Wikidoc.org, 2012, www.wikidoc.org/index.php/Cannabidiol.

Benefits
1.
May improve symptoms of anxiety by increasing serotonin transmission [1]
2.
Reduces withdrawal symptoms caused by dopamine dysregulation [2]
3.
Improves the efficacy of THC while reducing/preventing psychotic side-effects such as anxiety and paranoia [3]
Deficiency Factors

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Applications & Precautions
Applications
Alcohol Detox, Caffeine Detox, Sugar Detox
Precautions
Taking large doses of CBD can lead to drowsiness, especially late in the day.
Dosage Guidelines
Dosing Range
25
-
50
mg
Dose Increment
25
mg
Maximum Daily
150
mg
Best absorbed
sublingually
Recommended Products
CBD Oil 1000 mg - Irwin Naturals Order from Irwin Naturals 
CBD Full Spectrum 20 MG - Plnt Order from Vitamin Shoppe 

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References
1. 
De Gregorio, Danilo, et al. “Cannabidiol Modulates Serotonergic Transmission and Reverses Both Allodynia and Anxiety-like Behavior in a Model of Neuropathic Pain.” Pain, vol. 160, no. 1, 27 Aug. 2018, pp. 136–150, www.ncbi.nlm.nih.gov/pmc/articles/PMC6319597/, 10.1097/j.pain.0000000000001386.
2. 
Seeman, P. “Cannabidiol Is a Partial Agonist at Dopamine D2High Receptors, Predicting Its Antipsychotic Clinical Dose.” Translational Psychiatry, vol. 6, no. 10, Oct. 2016, pp. e920–e920, www.ncbi.nlm.nih.gov/pmc/articles/PMC5315552/, 10.1038/tp.2016.195.
3. 
Hudson, Roger, et al. “Cannabidiol Counteracts the Psychotropic Side-Effects of Δ-9-Tetrahydrocannabinol in the Ventral Hippocampus through Bidirectional Control of ERK1–2 Phosphorylation.” The Journal of Neuroscience, vol. 39, no. 44, 30 Sept. 2019, pp. 8762–8777, www.jneurosci.org/content/39/44/8762, 10.1523/jneurosci.0708-19.2019.
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These icons appear on items to indicate the affected neurotransmitter(s).
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Dopaminergic. promotes the synthesis or activity of dopamine.

Endorphinergic. promotes the synthesis or activity of endorphins.

noradrenergic

Noradrenergic. promotes the synthesis or activity of noradrenaline.

Cholinergic. promotes the synthesis or activity of acetylcholine.

gabanergic

GABAnergic. promotes the synthesis or activity of GABA.

Serotonergic. promotes the synthesis or activity of serotonin.

These icons appear on items to indicate the optimal time-of-day.
rising

Rising. sunrise to mid-morning.

2-midmorning

Morning. mid-morning to noon.

3-noon

Noon. noon to mid-afternoon.

5-sunset

Afternoon. mid-afternoon to sunset.

evening

Evening. sunset to bedtime.

These icons appear on items to indicate additional benefits & important alerts.

Synergistic. combining with another supplement may increase potency.

Methylation agent. increases or decreases methylation of neurotransmitters.

Cortisol modulator. affects the synthesis or activity of the stress hormone cortisol.

Glucose regulator. attenuates changes in blood sugar levels.

Johnathan Kobé
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