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Agmatine
 
augmentor
Summary

"Agmatine is the decarboxylation product of the amino acid arginine and is an intermediate in polyamine biosynthesis...Agmatine binds to α2-adrenergic receptor and imidazoline binding sites, and blocks NMDA receptors and other cation ligand-gated channels. Agmatine inhibits nitric oxide synthase (NOS), and induces the release of some peptide hormones. Treatment with exogenous agmatine exerts neuroprotective effects in animal models of neurotrauma."

“Agmatine - Wikidoc.” Wikidoc.org, 2012, www.wikidoc.org/index.php/Agmatine.

Benefits
1.
May reduce craving symptoms from alcohol withdrawal by upregulating endorphin release [4]
2.
May improve symptoms of burnout by increasing endorphin activity [1]
3.
May reduce symptoms of acute depression caused by neuroinflammation and glutamate dysregulation [1]
Deficiency Factors
Synergies
Supplement
Dose Range
Supplement
 
Dose Range
Lithium Orotate 5-30mg
The combination of lithium and agmatine can provide a strong 'mood stabilizing' effect, ideally for addressing depression caused by overstimulation of dopamine and/or glutamate receptors (ie. 'bi-polar' depression).
Applications
Alcohol Detox, Burnout
Dosage Guidelines
Dosing Range
500
-
1500
mg
Dose Increment
500
mg
Maximum Daily
3000
mg
Best absorbed
without food
Recommended Products
Agmatine Sulfate - Nutricost Order from Amazon 

See a list of verified product recommendations for [vg_display_data key=”post_title” data_source=”post_data”] when you signup for a support plan.

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References
1. 
Haroon, Ebrahim, et al. “Inflammation, Glutamate, and Glia: A Trio of Trouble in Mood Disorders.” Neuropsychopharmacology, vol. 42, no. 1, 15 Sept. 2016, pp. 193–215, www.ncbi.nlm.nih.gov/pmc/articles/PMC5143501/, 10.1038/npp.2016.199.
2. 
Shopsin, Baron. “The Clinical Antidepressant Effect of Exogenous Agmatine Is Not Reversed by Parachlorophenylalanine: A Pilot Study.” Acta Neuropsychiatrica, vol. 25, no. 2, 26 Feb. 2013, pp. 113–118, www.cambridge.org/core/journals/acta-neuropsychiatrica/article/abs/clinical-antidepressant-effect-of-exogenous-agmatine-is-not-reversed-by-parachlorophenylalanine-a-pilot-study/62BA83527CFA2D1F283A4899307103DE, 10.1111/j.1601-5215.2012.00675.x.
3. 
Chang, Chin-Hong, et al. “Increase of β-Endorphin Secretion by Agmatine Is Induced by Activation of Imidazoline I2A Receptors in Adrenal Gland of Rats.” Neuroscience Letters, vol. 468, no. 3, Jan. 2010, pp. 297–299, pubmed.ncbi.nlm.nih.gov/19913596/, 10.1016/j.neulet.2009.11.018.
4. 
Taksande, Brijesh G., et al. “Agmatine Inhibits Behavioral Sensitization to Ethanol through Imidazoline Receptors.” Alcoholism: Clinical and Experimental Research, vol. 43, no. 4, 6 Mar. 2019, pp. 747–757, onlinelibrary.wiley.com/doi/abs/10.1111/acer.13972, 10.1111/acer.13972.
5. 
Mohseni, Gholmreza, et al. “Agmatine Enhances the Antidepressant-like Effect of Lithium in Mouse Forced Swimming Test through NMDA Pathway.” Biomedicine & Pharmacotherapy, vol. 88, Apr. 2017, pp. 931–938, pubmed.ncbi.nlm.nih.gov/28178624/, 10.1016/j.biopha.2017.01.119.
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These icons appear on items to indicate the affected neurotransmitter(s).
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Dopaminergic. promotes the synthesis or activity of dopamine.

Endorphinergic. promotes the synthesis or activity of endorphins.

noradrenergic

Noradrenergic. promotes the synthesis or activity of noradrenaline.

Cholinergic. promotes the synthesis or activity of acetylcholine.

gabanergic

GABAnergic. promotes the synthesis or activity of GABA.

Serotonergic. promotes the synthesis or activity of serotonin.

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Noon. noon to mid-afternoon.

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evening

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These icons appear on items to indicate additional benefits & important alerts.

Synergistic. combining with another supplement may increase potency.

Methylation agent. increases or decreases methylation of neurotransmitters.

Cortisol modulator. affects the synthesis or activity of the stress hormone cortisol.

Glucose regulator. attenuates changes in blood sugar levels.

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Neurotransmitter Scores

Dopamine

 

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Endorphin

 

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Noradrenaline

 

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Acetylcholine

 

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GABA

 

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Serotonin

 

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