Agmatine
augmentor
Summary
"Agmatine is the decarboxylation product of the amino acid arginine and is an intermediate in polyamine biosynthesis...Agmatine binds to α2-adrenergic receptor and imidazoline binding sites, and blocks NMDA receptors and other cation ligand-gated channels. Agmatine inhibits nitric oxide synthase (NOS), and induces the release of some peptide hormones. Treatment with exogenous agmatine exerts neuroprotective effects in animal models of neurotrauma."
“Agmatine - Wikidoc.” Wikidoc.org, 2012, www.wikidoc.org/index.php/Agmatine.
Benefits
1.
May reduce craving symptoms from alcohol withdrawal by upregulating endorphin release [4]
2.
May improve symptoms of burnout by increasing endorphin activity [1]
3.
May reduce symptoms of acute depression caused by neuroinflammation and glutamate dysregulation [1]
Deficiency Factors
Synergies
ApplicationsAlcohol Detox, Burnout
Dosage Guidelines
500
1500
mg
500
mg
3000
mg
without food
Recommended Products
Agmatine Sulfate - Nutricost
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References
1.
Haroon, Ebrahim, et al. “Inflammation, Glutamate, and Glia: A Trio of Trouble in Mood Disorders.” Neuropsychopharmacology, vol. 42, no. 1, 15 Sept. 2016, pp. 193–215, www.ncbi.nlm.nih.gov/pmc/articles/PMC5143501/, 10.1038/npp.2016.199.
2.
Shopsin, Baron. “The Clinical Antidepressant Effect of Exogenous Agmatine Is Not Reversed by Parachlorophenylalanine: A Pilot Study.” Acta Neuropsychiatrica, vol. 25, no. 2, 26 Feb. 2013, pp. 113–118, www.cambridge.org/core/journals/acta-neuropsychiatrica/article/abs/clinical-antidepressant-effect-of-exogenous-agmatine-is-not-reversed-by-parachlorophenylalanine-a-pilot-study/62BA83527CFA2D1F283A4899307103DE, 10.1111/j.1601-5215.2012.00675.x.
3.
Chang, Chin-Hong, et al. “Increase of β-Endorphin Secretion by Agmatine Is Induced by Activation of Imidazoline I2A Receptors in Adrenal Gland of Rats.” Neuroscience Letters, vol. 468, no. 3, Jan. 2010, pp. 297–299, pubmed.ncbi.nlm.nih.gov/19913596/, 10.1016/j.neulet.2009.11.018.
4.
Taksande, Brijesh G., et al. “Agmatine Inhibits Behavioral Sensitization to Ethanol through Imidazoline Receptors.” Alcoholism: Clinical and Experimental Research, vol. 43, no. 4, 6 Mar. 2019, pp. 747–757, onlinelibrary.wiley.com/doi/abs/10.1111/acer.13972, 10.1111/acer.13972.
5.
Mohseni, Gholmreza, et al. “Agmatine Enhances the Antidepressant-like Effect of Lithium in Mouse Forced Swimming Test through NMDA Pathway.” Biomedicine & Pharmacotherapy, vol. 88, Apr. 2017, pp. 931–938, pubmed.ncbi.nlm.nih.gov/28178624/, 10.1016/j.biopha.2017.01.119.
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