Dopaminergic regulator. promotes homeostasis of the neurotransmitter dopamine.
Cholinergic. agents involved in the synthesis or activation of the neurotransmitter acetylcholine.
GABAnergic. agents affecting the action of the neurotransmitter GABA.
Serotonergic. agents involved in the synthesis or activation of serotonin.
Profile Summary
A list of the most common cannabis strains that belong to this profile. Use this as a shortcut to identify familiar genetics or discover new favorites that deliver the experience you’re looking for.
Common cultivars
Explore how the dominant terpenes target specific neurotransmitters to affect mood and cognitive performance.
Neurotypes
Each cannabis profile is matched to support the neurotransmitter combinations most affected by acute or chronic stress for specific neurotypes.
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Explore how the dominant terpenes target specific neurotransmitters to affect mood and cognitive performance.
Terpene Profile
Myrcene, known for its sedative and muscle-relaxing properties, enhances GABA activity by binding to GABA-A receptors, which produces anxiolytic and calming effects on the central nervous system. Additionally, it stimulates serotonin (5-HT) release and receptor activation, which also contributes to its mood-regulating and sleep-promoting effects.
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Primary Neurotransmitters
GABA
enhances the effects of endogenous GABA by increasing receptor sensitivity [1]
serotonin
stimulates serotonin release via receptor activation [2]
Pinene, known for its memory enhancing effects, boosts acetylcholine synthesis and stimulates the production of dopamine precursors. These combined actions underlie pinene’s cognitive-enhancing benefits, promoting alertness, focus, and learning.
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Primary Neurotransmitters
acetylcholine
promotes synthesis via upregulation of choline acetyltransferase [1]
dopamine
stimulates production of dopamine precursors [2]
Caryophyllene [kar-ee-o-phyl-leen], the only terpene that can be found in all types of cannabis, regulates dopamine release in reward-related brain regions, modulating reinforcement and motivational pathways. It also protects dopaminergic neurons from oxidative stress while mitigating glutamate-induced excitotoxicity. Together, these effects underlie caryophyllene’s promise for neuroprotection and the modulation of reward-driven behaviors.
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Primary Neurotransmitters
dopamine
regulates dopamine release in parts of the brain responsible for reward reinforcement [1]
protects dopamine neurons from oxidative stress [2]
glutamate
mitigates glutamate-induced excitotoxicity by inhibiting excessive glutamate release [3]
Primary Benefits
Applications
The specific balance between key cannabinoids like THC & CBD. Use these relative ratios to confirm a cannabis profile when reviewing products at a dispensary.
Active Compounds
Cannabinoids
Terpene Averages
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Discover your Neurotype
By identifying your unique neurotype, you can tailor your cannabis and supplement protocol to support your brain’s natural balance- helping you break free from cycles of burnout, low energy, and stress-driven habits.
Each neurotype responds to stress differently, shaping how your brain chemistry reacts and recovers in high-pressure moments and over the long haul.




