Vitamin C
cofactor
Summary
Vitamin C or L-ascorbate is an essential nutrient for higher primates, and a small number of other species. The presence of ascorbate is required for a range of essential metabolic reactions in all animals and plants. It is made internally by almost all organisms, humans being one notable exception...In humans, vitamin C is a highly effective antioxidant, acting to lessen oxidative stress, a substrate for ascorbate peroxidase, as well as an enzyme cofactor for the biosynthesis of many important biochemicals.
“Vitamin c - Wikidoc.” Wikidoc.org, 2012, www.wikidoc.org/index.php/Vitamin_C
Benefits
1.
may lower stress hormone by attenuating the release of cortisol [1]
2.
upregulates the synthesis of beta-endorphin [2]
3.
promotes the synthesis of noradrenaline from dopamine by serving as an essential cofactor [3]
Deficiency Factors
alcohol consumption, dietary insufficiency
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Applications & Precautions
ApplicationsAlcohol Detox, Burnout, Caffeine Detox, Sugar Detox
Important Notes
Ascorbyl Palmitate is a specific form of vitamin c that is both water and lipid soluble. Research has shown that this form is more bioavailable to brain tissue (compared to typical ascorbate) and therefore may be better suited for affecting neurotransmitters. [4]
Dosage Guidelines
200
400
mg
200
mg
800
mg
with food
Recommended Products
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References
1.
Peters, E. M., et al. “Vitamin c Supplementation Attenuates the Increases in Circulating Cortisol, Adrenaline and Anti-Inflammatory Polypeptides Following Ultramarathon Running.” International Journal of Sports Medicine, vol. 22, no. 7, Oct. 2001, pp. 537–543, pubmed.ncbi.nlm.nih.gov/11590482/, 10.1055/s-2001-17610.
2.
Carr, Anitra C., and Cate McCall. “The Role of Vitamin c in the Treatment of Pain: New Insights.” Journal of Translational Medicine, vol. 15, no. 1, 14 Apr. 2017, 10.1186/s12967-017-1179-7.
3.
Plevin, David, and Cherrie Galletly. “The Neuropsychiatric Effects of Vitamin c Deficiency: A Systematic Review.” BMC Psychiatry, vol. 20, no. 1, 18 June 2020, bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-020-02730-w, 10.1186/s12888-020-02730-w.
4.
Pokorski, Mieczysław, et al. “Ascorbyl Palmitate as a Carrier of Ascorbate into Neural Tissues.” Journal of Biomedical Science, vol. 10, no. 2, Mar. 2003, pp. 193–198, link.springer.com/article/10.1007/BF02256054, 10.1007/bf02256054
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